I like to recognize when a colleague's work gets good coverage in scientific or trade journals. My kudos go out to Joanna Hudson this time for her article "Choosing Liquid or Powedered Media" in April's issue of BioProcess International, page 18.
As pointed out in the article, the old automiatic choice to use powdered media at scale is less obvious now. Liquid in many cases becomes a much better option as the scale of manufacture at commercialization has come down due to improvements in cell productivity in culture, and because there have been many imporvements made to the disposable systems that can support commercial manufacturing now.
In fact, companies are actively choosing to design new plants to run on disposables to cut capital costs associated with installing so much stainless steel, and to increase their ability to run multi-product flexible facilities -- which increases their ability to be responsive to market conditions.
Under many circumstances, liquid media can and should commercial production instead of the powdered alternative in order to reap some of the benefits alluded to above.
Posted by Bruce Lehr Apr 18th 2013.