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My also-flawed understanding agrees @bigredbrurce - the mAb is targeted at soluble A-beta, thus helping it to be 'cleared' out of the body - and preventing it 1) from participating in plaque formation AS WELL AS 2) interfering with synaptic communications (which apparently the soluble forms - 'dimers' of two A-beta proteins - and more, 'oligomers' - do very effectively, disrupting synaptic transmission).


My understanding may be flawed but I believe the mAb is directed at soluble amyloid beta in the blood and thus renders this circulating material unavailable to participate in plaque formation.


i still cannot understand how does an antibody cross the blood brain barrier. I think modular antibody will have better chance. We had discussion about this drug like 7-8 years ago, and most of us don't think it is possible at the time to work. I hope it work, cause AD is a horrible disease.

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